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31-01-2017 à 20:52:11
Weight loss pills phen fen
There are risks for elevated heart rate in certain patients, and pregnant women are decidedly off-limits, due to concern for birth defects. The findings indicated that approximately 30 percent of people who had taken the combination up to 24 months had abnormal echocardiograms, even though they had no symptoms. However, the medical officer of the Food and Drug Administration (FDA), Leo Lutwak, insisted upon a black box warning of pulmonary hypertension risks. The term fen-phen was coined in 1994 when Pietr Hitzig and Richard B. Phentermine, at the time and even now, was not seen to be a culprit. One of the problems associated with the Fen-Phen drug was primary pulmonary hypertension, a heart and lung related condition. And so Phentermine is back, this time married to the anti-seizure medication Topiramate to promote weight loss. In 1996, a paper in the New England Journal of Medicine (NEJM) from the Mayo Clinic discussed clinical findings in 24 people who had taken fen-phen. But now we have another combination that could also foster cardiovascular risks such as increased heart rate, and other side effects. Washington, DC Fen-Phen, at one time a miracle weight loss drug that was pulled from the market due to grievous health concerns years ago, is back in part. The action was based on findings from doctors who had evaluated people taking these two drugs with echocardiograms, a procedure that can test the functioning of heart valves. Qsymia, apparently, takes advantage of the tendency of Topiramate to result in weight loss as a side effect, and the capacity of Phentermine to suppress appetite. The product was pulled from the market for heart risks and other side effects. But the expert panel, in the end, did an about-face and recommended approval of the drug two years later in a vote that could only be described as an overwhelming majority.


But some familiar concerns, akin to PPH and Fen-Phen, are back. Originally dubbed Qnexa, ABC News reports that the FDA required manufacturer Vivus to alter the name to avoid confusion with similarly-named drugs. The Fen-Phen of today, so to speak, is the weight-loss drug Qsymia. In 1984, researchers at the University of Rochester Medical Center reported that they had performed a double-blind, controlled clinical trial comparing phentermine alone, fenfluramine alone, a combination of phentermine and fenfluramine, and placebo, for weight loss in humans. Overweight Americans who have used Qsymia have said they are less hungry, and food tastes different--enough to foster a desire to eat less. This disease typically involves the aortic and mitral valves. The manufacturer says the new drug must be used in concert with a healthy diet and exercise. Adverse effects were less frequent with the combination regimen than with the other active (non-placebo) treatments. As of 1997, the FDA was continuing to receive reports of valvular heart disease in persons who had taken these drugs. In April 2005, American Lawyer magazine ran a cover story on the wave of fen-phen litigation, reporting that more than 50,000 product liability lawsuits had been filed by alleged fen-phen victims. But there are similarities with the Fen-Phen of old. Thus, severe obesity is, in itself a health risk.

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